Thousands of Americans make a living working in a reality beyond our own, Spirit Seekers follows two of them - Pat Gagliardo, a police accredited clairvoyant medium, and Bob Larson, the most prolific exorcist in the US who's waging a personal war against the Devil.

Pat's day in the spirit world begins with some "intuitive readings" with private clients, carries on to a consultation with a police detective to help out on a mysterious missing persons case. After a John Edward-style appearance in front of a large audience, Pat gets a late night call to help a terrified family experiencing poltergeist activity in their house. The medium locates the spirit of a dead 12 year-old boy and to complete her job, helps it move on from the void!

Interwoven with Pat's story, Spirit Seekers follows Bob Larson who has just arrived in Greenville, North Carolina to do battle with the devil. We see him in a marathon 5-hour exorcism of Angela, a middle-aged woman who, at the age of 17, made a pact with the devil. Bob then holds a rally where he helps close to four hundred audience members liberate their souls from demons.